Wednesday, July 31, 2019

Case Study: Clams about Gay Marriage Essay

This case study focuses on the gay marriages in different states. In Massachusetts the State Supreme court had a ruling that the state constitution did not agree with same-sex marriages. The only way they could grant licenses was if the legislative acted to give same-sex marriages. After this ruling in Massachusetts; in San Francisco, California the mayor ruled that they could not deny same-sex marriages. Many same-sex couples began to apply for marriage licenses and got the marriage license. The gay marriages started to attract the media and many television cameras. Soon after the California State Supreme Court said that the San Francisco mayor had exceeded his power and they told the city to stop issuing these state marriage licenses to gay couples. Courts in other states followed the Massachusetts ruling not allowing same-sex marriages. It then began to report that other foreign countries were allowing same-sex marriages to become legal. This started controversy in the United States because people in America think of marriage in a very sensitive way and that commitment it between two people who love each other. Advocates of gay marriage wanted to know why when two people are in love that they couldn’t be married. This began to raise issues for gay marriage not being legalized. Advocates were speaking out that it not only is about the commitment between the two people but also about the legal rights that the couples would obtain. The gay couples wanted the rights that a couple of a married man and women would get. They wanted to be able to get the medical rights and property rights of other normal married couples. Advocates also argued that they have their freedom also and they have the right to be in love with whomever they choose to be in love with. They just wanted the same equality as everyone else. In others terms they stated that same-sex marriage was wrong and it shouldn’t be allowed in the state. The argument then began again about marriage should be between one man and one woman. They also began to state that children that come from a household of a man and woman being married benefited them. They believed that if same-sex marriage became legal there would become a downfall in society. It wasn’t about the rights and freedom of same-sex couples but the image that America was to hold and how society is taught that one man and one woman should be married. In elections later in 2004 and 2006 conservative politicians wanted to have a same-sex marriage amendment to forbid it. The arguments for and against gay marriage became more and more heated as the years went on. As votes were shown most people wanted civil union laws. When the vote for same-sex marriage came about only a minority was for it. Gay and lesbian couples began to arrange ceremonies that were not legal unless legally allowed in the state. To this day debates, arguments, and court cases still go on about the fight for gay marriage. Questions 1. What grounds, warrants, and conclusions do advocates for gay marriage and their opponents use? The advocates say that besides two people being in love and making a commitment but that same-sex couples should have the freedom to love whomever they choose have the rights as any other one man and one woman married couple were to have. The opponents believe that for reasons for society and to keep the image and to not cause a downfall in America that only a man and woman should be legally married. 2. How did claims favor of gay marriage evolve from those of the earliest advocates to the more recent campaigns after the ruling by the Massachusetts state supreme court? I believe that the Massachusetts ruling was part of the start that caused the claims to start and from all of this evolved the more recent campaigns and the issues coming from gay marriage. 3. How did opponents to gay marriage change their counterclaims to respond to new arguments by advocates of gay rights? The opponents changed their counterclaims because they had to be able to have an argument back to the new responses of the gay rights advocates.

Tuesday, July 30, 2019

Dental Cavities And Water Fluoridation Health And Social Care Essay

Fluoridation of H2O is the controlled add-on of fluoride to a public H2O supply to cut down tooth decay. Fluoridated H2O has fluoride at a degree that is effectual for forestalling pits, this can happen of course or by adding fluoride. This pattern occurs chiefly in English-speaking states, as Continental Europe does non fluoridize public H2O supplies. Fluoridated H2O operates on tooth surfaces: in the oral cavity it creates low degrees of fluoride in spit, which reduces the rate at which tooth enamel demineralises and increases the rate at which it demineralises in the early phases of pits. A fluoridated compound is added to imbibing H2O, a procedure that in the United States costs an norm of about $ 0.94 per person-year. Bottled H2O typically has unknown fluoride degrees, and some domestic H2O filters take some or all fluoride. Dental pits remain a major public wellness concern in most industrialised states, impacting a bigger per centum of schoolchildren and the huge bulk of grownups. Water fluoridization prevents pits in both kids and grownups, with surveies gauging about 30 per centum decrease in pits when H2O fluoridization is used by kids who already have entree to toothpaste and other beginnings of fluoride. Water fluoridization can do dental fluorosis, which can change the visual aspect of developing dentitions. These are normally non considered to be of aesthetic or public-health concern. Fluoride ‘s effects depend on the entire day-to-day consumption of fluoride from all beginnings. Drinking H2O is typically the largest beginning ; other methods of fluoride therapy include fluoridization of toothpaste, salt, and milk. Water fluoridization, when executable and culturally acceptable, has significant advantages for subgroups at high hazard. The U.S. Centres for Disease Control listed H2O fluoridization as one of the 10 great public wellness accomplishments of the twentieth century. In contrast to most European states, who experienced significant diminutions in tooth decay without its usage due to the debut of fluoride toothpaste in the seventiess. Fluoridation may be more justified in the U.S. because of socio-economic inequalities in dental wellness and dental attention. The end of H2O fluoridization is to forestall a chronic disease whose jobs peculiarly fall on kids and on the hapless. The usage of H2O fluoridization creates a struggle between the common good and single rights. Health and dental organisations worldwide have endorsed its safety and effectivity. Its usage began in 1945, following surveies of kids in a part where higher degrees of fluoride take topographic point of course in the H2O. Research workers discovered that moderate fluoridization prevents tooth decay and as of 2004 about 400 million people worldwide received fluoridated H2O. Fluoridation besides prevents tooth decay by seting the concentration of fluoride in public H2O supplies. Tooth decay is one of the most prevailing chronic diseases worldwide. Even though it is seldomly dangerous, tooth decay can do ; hurting and impair feeding, speech production, facial visual aspect, and credence into society, it greatly affects the quality of life of kids, peculiarly those of low socio-economic position. Fluoridation does non impact the visual aspect, gustatory sensation, or odor of imbibing H2O. Normally it is made by adding one of three compounds to the H2O: Na fluoride, fluorosilicic acid, or Na fluorosilicate. Sodium fluoride ( NaF ) was the first compound used and is the mention criterion. It is a white, odourless pulverization ; the crystalline signifier is preferred if physical handling is used, as it minimizes dust. Fluorosilicic acid ( H2SiF6 ) is an cheap liquid byproduct of phosphate fertiliser industry. It contains so much H2O, transportation can be expensive Sodium fluorosilicate ( Na2SiF6 ) is a really all right crystal that is easier to transport than fluorosilicic acid. Among the chief benefits of fluoridization are: Community H2O fluoridization is an effectual, safe, and cheap manner to forestall tooth decay. This method of fluoride bringing benefits of all ages and despite socioeconomic position. Brushing twice a twenty-four hours with a fluoride toothpaste is an easy manner to forestall tooth decay. Fluoridation, which was started in Grand Rapids, Michigan in 1945, has been used successfully in the United States for more than 50 old ages. Fluoride plants by change by reversaling the decay procedure. It keeps tooth enamel strong and solid.A Community H2O fluoridization is considered one of 10 great public wellness accomplishments of the twentieth century. Of the 50 largest metropoliss in the United States, 42 have community H2O fluoridization. Fluoridation reaches 69 per centum of the population on public H2O supplies this is more than 184 million people.A Communities with fluoridated imbibing H2O in the United States, Australia, Britain, Canada, Ireland, and New Zealand show dramatic decreases in tooth decay-those with fluoridated imbibing systems have less percent tooth decay. About all tooth decay can be prevented when fluoridization is combined with dental sealers and other fluoride merchandises, such as toothpaste.A Fluoride dietetic addendums can supply fluoride to those who do non hold equal degrees in their imbibing H2O. They are available as tablets, beads, or lozenges. Over-the-counter fluoride dental merchandises such as toothpastes and oral cavity rinses are effectual in forestalling decay. Merchandises with high concentrations of fluoride that are applied in the dental office or prescribed for place usage offer extra protection for those at increased hazard of tooth decay.A Fluoride will go on to be of import for forestalling tooth decay in this age group. Older Americans are particularly susceptible to tooth decay because of open root surfaces and oral cavity waterlessness that may ensue from many medicines. The hazards of fluoridization Fluoride was foremost added to H2O supplies in Grand Rapids, in 1945 to forestall tooth decay. The pattern has had some controversial with some claiming it does small to forestall tooth decay and is unsafe for wellness. Most tooth doctors and public wellness functionaries province that it significantly lowers the rates of tooth decay and presents no of import wellness hazards. A bigger per centum of United States population drinks fluoridated H2O. But on contrary when towns and metropoliss across the state hold elector referenda on fluoridization, its usage has been rejected about half the clip. The long-running argument over fluoride usage and exposure was the topic of a citizens ‘ conference held at St. Lawrence University, on July 28-30. Most research workers report on fluoride did non measure the safety or benefits of H2O fluoridization. But did address specifically the current maximal degree of natural fluoride EPA allows in imbibing H2O and concluded nem con that fluoride at that concentration harms dentitions and castanetss. A life-time of fluoride consumption in countries where the H2O is fluoridated at approximately 1 ppm can alter the quality of dentin and bone and may increase break rates for both. Kidney patients and diabetics are at particular menace from fluoridated H2O because they tend to imbibe more liquid than healthy persons. Bottle-fed babies are besides at particular hazard if expression is assorted with fluoridated H2O. Peoples drink widely different sums of fluoridated H2O and other beginnings of exposure vary as in U.S persons are having immensely different doses of fluoride. Fluoride at degrees found in imbibing H2O affects encephalon map in grownups the research workers report indicates that the receptor cells in the encephalon can change in response to toxins and fluoride. Fluoride impairs the encephalon ‘s ability to transport out signalling maps, with the effect that messages that are passed along the many tracts that are likely to be uncomplete. It does this by interrupting the creative activity and dislocation of neurofilaments in the axons of nerve cells. It besides interferes with both primary and secondary signalling in the nervous system. Fluoride may besides increase the figure of plaques and tangles in the encephalons of grownups, which could lend to dementia. These surveies were done by Isaacson utilizing rats, chronic exposure to sodium fluoride or aluminum fluoride in imbibing H2O, where by it led to plaques and tangles in the rats ‘ encephalons that are similar to the abnormalcies found in Alzheimer ‘s patients. It appears furthermore that exposure to fluoride in the uterus and throughout early life lowers intelligence. The Epidemiologic surveies suggest that fluoridization of imbibing H2O decreases the figure of kids at the really bright terminal of the IQ spectrum and increases the figure in the low IQ part the study says. Moderate fluorosis involves xanthous or brown mottling of dentition from inordinate fluoride exposure, occurs at rates somewhat high per centum in some fluoridated communities. Teeth with moderate fluorosis besides have weaker dentin with increased tubule size, he said. â€Å" This may do grownup teeth break more easy. In decision the benefit of H2O fluoridization as reference include ; reduced tooth decay, may merely be a map of delayed tooth eruption. It is known that lasting dentitions take longer to break out in kids who drink fluoridated H2O. Studies comparing decay rates in fluoridated and non-fluoridated communities normally assess the average figure of rotten, losing, and filled surfaces in lasting dentitions of 12-year-old kids. Thus its advisable to take fluoride out of the H2O supply, and utilize the money spent for fluoridization to advance better public wellness..

Monday, July 29, 2019

History of Latin America Essay Example | Topics and Well Written Essays - 750 words - 1

History of Latin America - Essay Example he financial means for Spain that allowed it to dominate Europe for nearly one hundred years.4 Mining silver, however, was not an uncomplicated business undertaking and required planning and workforce management strategies. The Spaniards developed labor systems that were not beneficial to the natives, however. The discovery of silver in Spanish America changed the lives of natives through developing the mita service and importing black slaves, which transformed the latter’s socio-economic, demographic, and cultural characteristics. The industry of silver mining was the biggest and most complex industries in the Indies, which altered the economic and social infrastructures of the natives in different degrees through its innovations with the mita system. Silver mining was concentrated in north central Mexico and the highlands of Upper Peru.5 Mining it needed a massive workforce with a combination of skilled and unskilled laborers.6 The skilled laborers maintained the shafts, drainage, and ventilation systems, while the unskilled ones extracted the ore from the pits.7 The state changed the economic and social organization of the natives, in order to fit the labor needs of the silver mines.8 The Spaniards developed its specialized workforce system through combining private organizational efforts and state-controlled public services.9 In Peru, Don Francisco Toledo elaborated Spain’s forced labor system through combining Inca-based mita system and recently made Spanish labor practices.10 The mita system oblig ed native adult laborers to work at faraway mines. Miners received very poor remuneration and worked at perilous mine conditions. They were paid in silver, but the costs of food, lodging, tools, and clothing left them with nothing. The owners of the mines made extra money from selling these basic commodities to the natives, since the mines were far from communities. In Mexico, native families experienced socio-economic transition from being communal-work based

Sunday, July 28, 2019

Hillingdon Electricals Ltd Coursework Example | Topics and Well Written Essays - 3000 words

Hillingdon Electricals Ltd - Coursework Example Moreover, building strong relationship with its business partners along with enhancing its reputation has also facilitated HEL to obtain significant values within its operating areas. However, since the last two years, HEL has been experiencing a significant decline of its market shares due to the rising competition in the respective business industry along with instability of the global economy. The consequences of significant losses incurred in the market share, resulted to an increase in the target set for its retail stores through the implementation of higher pricing strategy for its wide range of households and electronic products. Moreover, the company has also been identified to implement higher promotional activities in order to refurbish the annual sales of its retail stores. The strategy of changing business policies or regulations was highly motivated the organisation to cope with the potential challenges caused by the market competition and economic instabilities. Corresp ondingly, the case scenario of HEL demonstrates three major scenarios regarding the difficulties faced by the organisation with respect to the legal regulations and policies. The company has conducted a wide range of advertising programs through different media to publicise its newly developed pricing structure for the products offered by its retail outlets. According to the advertisement results, it has been observed that the newly built pricing structure has incorporated numerous issues associated with the price of each individual product that are significantly cheaper than other marketers. In this regard, the following discussion of the study includes a brief demonstration of each scenario and justifies effective legal policies for the organisation to evade its potential challenges. Scenario A - Tony and Ursula In relation to the issues observed in the case scenario, indicating to the challenges faced by Tony and Ursula, an error as recognised associated with the pricing strategy of the products offered by each individual store of HEL to be the base point of the conflicts witnessed by HEL. In this context, Tony, a customer of the retail store of HEL had accepted the offer made by the company and purchased an iPad from the company’s online website in a price that was published by the organisation through its advertisements. However, the company claimed that advertised price was erroneous due to a manual mistake and that the actual price of the product was much higher. Although, the retail store had also offered different promotional offers to uphold itsgoodwill, Tony refused to pay the actual market price of the product and bargained the product at the advertised price. In the similar context, another customer Ursula had also faced similar issue during the purchase of product Tablet from the retail store, which was similarly advertised at a cheap price as compared to its market price. Subsequently, HEL made a repeat offer to Ursula at a discounted by a higher price of the product, who further denied paying the actual amount against the product to the store. In relation to the brief synopsis of the scenario of Tony and Ursula, it can be apparently stated that the pricing structure of the products developed by HEL is associated

Sales of Goods by Sea Essay Example | Topics and Well Written Essays - 750 words

Sales of Goods by Sea - Essay Example The law that governs contracts for the sale of goods entrenched in The Sale of Goods Act 1979 plus 1994 amendments. Merchant B is not supposed to pay Merchant B as supported by the argument below’ â€Å"The seller had the obligation of advising the buyer of the impending war between the two states once he became aware.† On evaluation of the risks of the goods while on transit on the sea, there is a strong link risk allocation. As the seller is in physical possession of goods prior to selling, he has the obligation of assuming the measures of preventing risks (Bernd 1). Before the goods left physical possession of the seller to the carrier, he had the responsibility of advising the buyer the probable outcome of the war such that the buyer could have been aware and accepts to assume the risk. The risk of the cargo is passed to the buyer once goods have been delivered.1 Therefore, the seller (Merchant A) having assumed first physical possession of the goods and keeping in mind that the buyer (Merchant B) had not yet assumed any practical possession of the goods leaves the seller at the legal entity responsible for the cargo. Upon delivery of shipping documents, there is no evidence of goods delivery, thus, Merchant B has not fulfilled his contractual duty to claim meeting his contractual part (Bernd 1). Since the Merchant B had the custody of shipping documents, he is obligated to advice the buyer on any impending risks that may render the goods faulty of not getting to the port of Calais on time (Bernd 1). The reason that goods have not arrived the port of destination does not imply non shipment, but rather, there may be eventualities that the goods have not arrived due to war between France and England. â€Å"It is the obligation of the seller to ascertain the exact state of the goods; whether destroyed of cargo sought refuge at a port in Spain† As per the contract of the case in question, the goods were to be delivered from Dover to Calais. The seller has the obligation of shipping the goods that the answer to the contract (Stone and Carr 39). As stated in section 13 of the Sale of Goods Act 1979,2 that where the contract is for sale of goods by description, the goods ought to correspond to the description. According to Section 2, sub. 5: Under the contract, the transfer of goods from Merchant A to Merchant B was to take place in the future upon delivery at Calais to fulfill the contract to be regarded as an agreement of sale. The agreement becomes a sale upon meeting conditions subject to which goods are transferred. Whether the ship; or goods on board are safe, is not the responsibility of the buyer but the seller. This clearly implies that the goods if happened to have encountered shipment risks of perils of the sea are liable to be indemnified by relevant insurer (Simone 95). The seller being well aware of the conditions surrounding the shipment of the goods, has the obligation of following up to ascertain the sta te of the shipment to ascertain the real situation to ensure terms of contract are met.3 Incorporating the incoterms relating to the contract, a contract of insurance entered into, defines the compensation of goods on transits in case of peril of the sea or any other risk that the cargo may be exposed to.4 For a contract to be termed valid and legally binding it must meet several requirements. Since the contract between A and B had requirements that the goods had to be

Saturday, July 27, 2019

Challenges and Solutions to Organizational Knowledge Management in Essay

Challenges and Solutions to Organizational Knowledge Management in KBMS - Essay Example Basically, a knowledge base is a special kind of database for knowledge management. According to Bellinger, Castro, & Mill, knowledge is defined as the application of data and information; answers "how" questions. It deals with collection of information such that its intent is to be useful. In an organization, knowledge is used on the day to day basis in the running of the affairs of the company. Andriopoulos & Dawson (20) suggest that managing change, creativity & innovation is the most crucial aspect for organisations to survive as we move into a knowledge economy. Knowledge is used in the operations of the organization so that it can achieve its desired goals. The main challenge of managing knowledge is that it is not static given that it changes depending on the changes taking place in the environment in which the organization operates. During the contemporary period, it can be noted that organisations operate in a dynamic environment which changes on a daily basis. In order to keep pace with these changes, the organization ought to develop and manage knowledge that can be used in the operations of the company. Since knowledge is not static, it can be seen that what was previously regarded as useful knowledge to the organization may not be relevant in the future operations of the organization. Therefore, this is a challenge to the organization since it ought to upgrade its knowledge system periodically so as to be able to keep pace with the changes and developments that can take place in the environment in which it operates. This may not be an easy task since it may be difficult to predict what is seen as important in managing knowledge in the company. In order to deal with the above mentioned challenge, particular attention should be paid to continued learning in the organization which can help it to gain a competitive edge over other rival competitors operating in the same environment. According to Schultz (164), learning in an organization is

Friday, July 26, 2019

English grammar and spelling Essay Example | Topics and Well Written Essays - 1250 words

English grammar and spelling - Essay Example The part that I am doing is making a program by using Microsoft Visual Basic. It can control the wireless robot by the tool panel program, which is made in Visual Basic, by using the serial communication system to send the characters through the COM port to be received by the robot wireless device. In controlling the robot movement in different directions, for example; the Visual Basic Program sends character "E" for moving forward and "C" for backward, "S" for left and "F" for right and "D" for stopping the movement. In addition to making a screen in Visual Basic program, the user is able to view the live video directly by changing the size of the screen. The user can control the robot by pressing buttons. Apart from my own efforts, the success of any project depends largely on the encouragement and guidelines of my instructors. I would like to show my greatest appreciation to my instructors for allowing me to explore fields like Robotics and Image processing. I am grateful for their constant support and help. The characterization of the BASIC language is easy to use and easy to learn. Most copies and versions of BASIC language allows the user to communicate with the computer directly. BASIC is used in the fields of science and commercial, as well as other areas. The Visual Basic program is one of the best programs for beginners. Also, the Visual Basic language is easier than C++ and Java. It is a programming language that is considered to be one of the most important computer languages in use today. The original name was Basic, but then it developed to become Visual Basic. Visual language is easy to learn, simple, powerful and famous. It also requires some logical thinking, though it is an easy way for most of the beginners to make programs specifically for them. For example, to facilitate their tasks of their daily jobs. The programming of the robot involves working on developing the capacity of some interested groups from the community; there

Thursday, July 25, 2019

Equipment Specification Assignment Example | Topics and Well Written Essays - 750 words

Equipment Specification - Assignment Example This large capacity unit is ideal for constant drying, curing and baking during high-volume food processing. Electrical specifications of the oven shall be 220Volts, 50/60 Hertz and 16.5 Amps and the oven has a 24-month warranty. Enter ‘Set point mode’ on the controller by pressing UP or DOWN arrow pads one time. Digital display will start to blink, turning from bright to dim. The current set point is showed by the digital display while blinking. Adjust the Set point using UP and DOWN arrow keys. Make sure the High Limit Thermostat is turned to maximum position until the oven has stabilized the required Set temperature. [Oven shall need around 24 hrs to get stabilized into the set point temperature] Keep a certified reference thermometer inside the oven chamber or through the access tube at top left. Make sure thermostat is not in contact with the shelves. Check temperature in every hour until the reading is not changing anymore and compare the reading of the digital display with that of the reference thermometer. If there is a considerable difference between the two readings, put the display into ‘calibration mode’ by pressing both UP and DOWN arrow keys simultaneously until the display starts to flash. Adjust the temperature using the UP and DOWN arrow keys while flashing. Allow the oven temperature to stabilize and recalibrate if necessary. When the oven is stable at the desired set point (see 3 and 4 above), turn the Safety Thermostat counterclockwise till the OTP light turns â€Å"ON† and then turn the Safety Thermostat clockwise just until the OTP light turns ‘OFF†. Next, turn the thermostat clockwise two smallest divisions of the scale past the point where the lights went out to set the Safety Thermostat at a temperature approximately 100C above Main Temperature Set Point. Ten minute function – Push RESET pad. Blinking decimal

Wednesday, July 24, 2019

Business Planning Assignment Example | Topics and Well Written Essays - 4000 words

Business Planning - Assignment Example Business Plan is consist of three portion planning. They are marketing plan, Operation plan, and financial plan. Considering the mentioned areas planning has developed the Business Plan for Charm Company. The hard and soft system factors need to be addressed by the manager carefully to make a successful business plan. Carefully evaluation is very important companies. Fully costed business plans are prepared and defended in some specific ways. "Best practice" is sometimes controversial. So company authority needs to carefully think and take best practice. And it is needed to implement precisely. A business plan is a formal arrangement of a set of business goals, the causes why they are believed attainable, and the plan for achieving the desired goals. A business plan also contains background information of the organisation or team who are attempting to reach those goals. Profit-oriented Business Plans usually focus on financial goals whereas non-profit and government agency Business Plans tend to focus on service goals. A business plan that has changes in view and branding as its primary goals is known as a marketing plan. Business plans may have focus on both internally or externally. Externally focused plans are important for external and financial stakeholders, sometimes investors, customers, and donors. Internally focused Business Plans consider intermediate goals needed to reach the external one. Internally focused plans include the development of a new product, a new service, a new IT system, a redistribution of finance, the refurbishing of a factory or a redesigning of the organisation. Here we will see how a business plan not only considering either internal or external, but focusing the both have been developed. And for this, we have chosen Italian Charm Company. Overview of Italian Charm Company: Charm Company is an Italian Company, which is located in Branson, Missouri at "The Marketplace" Shopping Centre. Their normal business hours are Monday to Saturday 10am - 6pm. They emphasize on the importance of customer service. Their knowledgeable staff members are not only friendly, but also charm enthusiasts tic. If the customers feel a charm is lacking in quality or design, Charm Company doesn't sell that showing respect to the customers. Their only goal is to bring their consumers with the finest quality charms, beads, and watches at reasonable prices. They accept VISA, MasterCard, and money order etc. All of their charms, watches and beads are handcrafted (fully made by hand, not by machine) in Italy from materials including 18-karat gold, real silver, cubic zircons, semi-precious stones, premium enamel, and stainless steel. Role,

Tuesday, July 23, 2019

Business Law Core Case Study Example | Topics and Well Written Essays - 3000 words

Business Law Core - Case Study Example This can be enumerated as follows:- 1. Agreement: - the first essential element of partnership is agreement. It is a relation between persons who have agreed to share profits. There can be no partnership without an agreement. Therefore the relation of partnership arises from contract and not from status. 2. Business: - The second essential element of partnership is "business" because without business there can be no partnership. Business includes every trade, occupation and profession. It is not necessary that the business should be of long standing and permanent. A single commercial transaction may constitute a business (Abenneim (1913) 109 LT 219, 220). According to Lindley (Lindley on partnership, fourteenth Edition. P.116) if the persons are not already partners, share profits and losses of a particular transaction, they may be partners for the said particular transaction. 3. Sharing of profits: - Another essential element of partnership is sharing of profits of a business. If two or more persons agree to carry on a business but their objective or motive is not to share profits, it shall not constitute a partnership. Thus sharing of profits or participation in profits of a business is one of the important essential elements of partnership. Prior to 1860 this essential element was considered so much important that if two or more persons agreed to carry out a business with the objective of sharing profits, it was considered to be decisive of constituting a partnership between them. In 1860 the decision in Cot v. Hick man (1860) 8 HLC 268) brought about a revolutionary change in this respect. Delivering the judgment Lord Cranworth of the House of Lords said that sharing of profits is good evidence that the business in which profits have been incurred is being carried on behalf of the persons who are sharing profits. In other words, sharing of profits is prima facie evidence of partnership. But the decisive test is mutual agency. The real basis of liability is that the business is being carried on behalf of the persons sharing profits. 4. Manual agency: - if two or more persons agree to carry on a business to share profits, it is still possible that the partnership may not come into in order to constitute a partnership in addition to the above noted three elements, the case of Cox v. Hickman (supra) deserves a special mention in this connection. Lord justice Lindley defined company as "an association of many persons who contribute money or money's worth to a common stock and employ it for a common purpose (Dr. N. C. Paranjape, company law, 2002). In undertaking the operations of the hotel and restaurant, both parties need to form ad incorporate the company either by special statute or by registration under the companies Act for the time being in force. Further the company many also be incorporated by Royal charter which is perhaps the oldest mode of incorporation. Therefore the means that it means that if David and Angela decide to run their business as a company then their property will be the partnership it is appropriate as their property will continue to be theirs and they will only share profits and losses of the company. There are several disadvantages and advantages of using partnership over a company in the prevailing case of David and Angela. These can

Monday, July 22, 2019

Civil Engineering Essay Example for Free

Civil Engineering Essay The material used for construction or the materials used to produce other materials which may be used in construction is called construction material. construction material are: Cement,sand ,water. Concrete, Lime, Stones, Paints and Varnishes, Wood and Timber, Engineering Metals, Bituminous materials and Plastics, Rubber and Glass, Miscelleneous materials, http://www.aboutcivil.org/engineering-materials.html Cement Bricklayer Joseph Asp din of Leeds, England first made portland cement early in the 19th century by burning powdered limestone and clay in his kitchen stove. Portland cement, the basic ingredient of concrete, is a closely controlled chemical combination of calcium, silicon, aluminum, iron and small amounts of other ingredients sand to which gypsum is added in the final grinding process to regulate the setting time of the concrete. Lime and silica make up about 85% of the mass. Common among the materials used in its manufacture are limestone, shells, and chalk or marl combined with shale, clay, slate or blast furnace slag, silica sand, and iron ore. Strength of cement Also known as the mother of all engineering, it is the oldest, most simple and useful of all engineering sciences. Civil engineering is field of engineering sciences, related to construction, design and maintenance of buildings, dams, bridges, tunnels, highways etc. sand Sand is an extremely needful material for the construction but this important material must be purchased with all care and vigilance. Sand which is used in the construction purpose must be clean, free from waste stones and impurities. It is important to know what type of sand is beneficial for construction purpose as sand is also classified into three different forms that make it suitable for specific type of construction. Sand is classified as: Fine Sand (0.075 to 0.425 mm), Medium Sand (0.425 to 2 mm) and Coarse Sand (2.0 to4.75 mm). However this classification of sand is further has types of sand in particular and on that basis only they are being incorporated in the construction. Read out the detailing of the types of sand: Pit Sand (Coarse sand) Pit sand is classified under coarse sand which is also called badarpur in common language. This type of coarse sand is procured from deep pits of abundant supply and it is generally in red-orange colour. The coarse grain is sharp, angular and certainly free from salts etc which is mostly employed in concreting. River Sand River sand is procured from river streams and banks and is fine in quality unlike pit sand. This type of sand has rounded grains generally in white-grey colour. River sand has many uses in the construction purpose such as plastering. Sea Sand As the name suggest, sea sand is taken from seas shores and it is generally in distinct brown colour with fine circular grains. Sea sand is avoided for the purpose construction of concrete structure and in engineering techniques because it contains salt which tends to absorb moisture from atmosphere and brings dampness. Eventually cement also loses its action when mixed with sea sand that is why it is only used for the local purpose instead of structural construction. There are different standards for the construction purpose which must be checked and considered for the better construction. The requirement according to which sand is chosen should be like: * For plastering purpose the overall fine sand used must not be less than 1.5 while silt is preferred to not less than 4 percent. * For brick work fine sand used must not be less than 1.2 to 1.5 and silt is preferred is 4 percent generally. * Concreting work require coarse sand in modulus of 2.5 to 3.5 with not less than 4 percent silt content. * http://www.sereneinteriors.com/building-construction/types-of-sand-construction.html water Pure and hygienic water is not only important for our life but also needed for quality construction. From the foundation till the completion of construction we must ensure the quality of water used. Here are few tips to know about water. Water is one of the most important elements in construction but people still ignore quality aspect of this element. The water is required for preparation of mortar, mixing of cement concrete and for curing work etc during construction work. The quality and quantity of water has much effect on the strength of mortar and cement concrete in construction work. Quality of Water The water used for mixing and curing should be clean and free from injurious quantities of alkalis, acid, oils, salt, sugar, organic materials, vegetable growth and other substances that may be deleterious to bricks, stone, concrete or steel. Potable water is generally considered satisfactory for mixing. The pH value of water should be not less than 6. Effects of Bad Quality Water on Cement Concrete It has been observed that certain common impurities in water affect the quality of mortar or concrete. Many times in spite of using best material i.e. cement, coarse sand, coarse aggregate etc. in cement concrete, required results are not achieved. Most of Engineers/Contractors think that there is something wrong in cement, but they do not consider quality of water being used. Some bad effects of water containing impurities are following. * Presence of salt in water such as Calcium Chloride, Iron Salts, inorganic salts and sodium etc. are so dangerous that they reduce initial strength of concrete and in some cases no strength can be achieved. There is rusting problem in steel provided in RCC. Â  Presence of acid, alkali, industrial waste, sanitary sewage and water with sugar also reduce the strength of concrete. ï‚ · Presence of silt or suspended particle in water has adverse effect on strength of concrete. Presence of oil such as linseed oil, vegetable oil or mineral oil in water above 2 % reduces the strength of concrete up to 25 %. 5. Presence of algae/vegetable growth in water used for mixing in cement concrete reduce of the strength of concrete considerably and also reduce the bond between cement paste and aggregate. Concrete. Concrete is a composite construction material composed primarily of aggregate, cement, and water. There are many formulations, which provide varied properties. The aggregate is generally a coarse gravel or crushed rocks such as limestone, or granite, along with a fine aggregate such as sand. The cement, commonly Portland cement, and other cementitious materials such as fly ash and slag cement, serve as a binder for the aggregate. Various chemical admixtures are also added to achieve varied properties. Water is then mixed with this dry composite, which enables it to be shaped (typically poured) and then solidified and hardened into rock-hard strength through a chemical process called hydration. The water reacts with the cement, which bonds the other components together, eventually creating a robust stone-like material. Concrete has relatively high compressive strength, but much lower tensile strength. For this reason it is usually reinforced with materials that are strong in tension ( often steel). Concrete can be damaged by many processes, such as the freezing of trapped water. Types of Concrete. Mix design Modern concrete mix designs can be complex. The choice of a concrete mix depends on the need of the project both in terms of strength and appearance and in relation to local legislation and building codes. The design begins by determining the requirements of the concrete. These requirements take into consideration the weather conditions that the concrete will be exposed to in service, and the required design strength. The compressive strength of a concrete is determined by taking standard molded, standard-cured cylinder samples. Many factors need to be taken into account, from the cost of the various additives and aggregates, to the trade offs between, the slump for easy mixing and placement and ultimate performance. A mix is then designed using cement (Portland or other cementitious material), coarse and fine aggregates, water and chemical admixtures. The method of mixing will also be specified, as well as conditions that it may be used in. This allows a user of the concrete to be confident that the structure will perform properly. Various types of concrete have been developed for specialist application and have become known by these names.. Concrete mixes can also be designed using software programs. Such software provide the user an opportunity to select their preferred method of mix design and enter the material data to arrive at proper mix designs. Old concrete recipes Concrete has been used since ancient times. Regular Roman concrete for example was made from volcanic ash (pozzolana), and hydrated lime. Roman concrete was superior from other concrete recipes (for example, those consisting of only sand and lime)[1] used by other nations. Besides volcanic ash for making regular Roman concrete, brick dust can also be utilized. Besides regular Roman concrete, the Romans also invented hydraulic concrete, which they made from volcanic ash and clay. Modern concrete Regular concrete is the lay term describing concrete that is produced by following the mixing instructions that are commonly published on packets of cement, typically using sand or other common material as the aggregate, and often mixed in improvised containers. The ingredients in any particular mix depends on the nature of the application. Regular concrete can typically withstand a pressure from about 10 MPa (1450 psi) to 40 MPa (5800 psi), with lighter duty uses such as blinding concrete having a much lower MPa rating than structural concrete. Many types of pre-mixed concrete are available which include powdered cement mixed with an aggregate, needing only water. Typically, a batch of concrete can be made by using 1 part Portland cement, 2 parts dry sand, 3 parts dry stone, 1/2 part water. The parts are in terms of weight – not volume. For example, 1-cubic-foot (0.028 m3) of concrete would be made using 22 lb (10.0 kg) cement, 10 lb (4.5 kg) water, 41 lb (19 kg) dry sand, 70 lb (32 kg) dry stone (1/2 to 3/4 stone). This would make 1-cubic-foot (0.028 m3) of concrete and would weigh about 143 lb (65 kg). The sand should be mortar or brick sand (washed and filtered if possible) and the stone should be washed if possible. Organic materials (leaves, twigs, etc.) should be removed from the sand and stone to ensure the highest strength. High-strength concrete High-strength concrete has a compressive strength greater than 40 MPa (5800 psi). High-strength concrete is made by lowering the water-cement (W/C) ratio to 0.35 or lower. Often silica fume is added to prevent the formation of free calcium hydroxide crystals in the cement matrix, which might reduce the strength at the cement-aggregate bond. Low W/C ratios and the use of silica fume make concrete mixes significantly less workable, which is particularly likely to be a problem in high-strength concrete applications where dense rebar cages are likely to be used. To compensate for the reduced workability, superplasticizers are commonly added to high-strength mixtures. Aggregate must be selected carefully for high-strength mixes, as weaker aggregates may not be strong enough to resist the loads imposed on the concrete and cause failure to start in the aggregate rather than in the matrix or at a void, as normally occurs in regular concrete. In some applications of high-strength concrete the design criterion is the elastic modulus rather than the ultimate compressive strength. Stamped concrete Stamped concrete is an architectural concrete which has a superior surface finish. After a concrete floor has been laid, floor hardeners (can be pigmented) are impregnated on the surface and a mold which may be textured to replicate a stone / brick or even wood is stamped on to give an attractive textured surface finish. After sufficient hardening the surface is cleaned and generally sealed to give a protection. The wear resistance of stamped concrete is generally excellent and hence found in applications like parking lots, pavements, walkways etc. High-performance concrete High-performance concrete (HPC) is a relatively new term used to describe concrete that conforms to a set of standards above those of the most common applications, but not limited to strength. While all high-strength concrete is also high-performance, not all high-performance concrete is high-strength. Some examples of such standards currently used in relation to HPC are: Properties of concrete. Uses of concrete. Concrete is widely used for making architectural structures, foundations, brick/block walls, pavements, bridges/overpasses, motorways/roads, runways, parking structures, dams, pools/reservoirs, pipes, footings for gates, fences and poles and even boats. Famous concrete structures include the Burj Khalifa (worlds tallest building), the Hoover Dam, the Panama Canaland the Roman Pantheon. Lime. Manufacture of lime Lime stones are burnt in either clamps or kilns.1. Clamps:For small quantity of limestone, burning is done in a clamp. On a clear surface about 5 meters in diameter, layers of broken limestones and fuel are laid to form a heap about 4 meters high.First and the last layers should be of the fuel. In case coal is used as fuel, it could be well mixed up with limestones and lay in a heap. Sides of the heap, which incline slightly inwards, are plastered over with mud to stop loss of heat. A little opening at the top is provided for draught. The clamp is then fired at the bottom.Disappearance of blue flame at the top is an indication of the burning of lime having completed. The clamp is then allowed to cool down and pieces of quick lime are then handpicked.Clamp burning of lime is uneconomical as the fuel consumption is more due to loss of heat and as some lime powder is lost in fuel ash. Also the quick lime carries any admixture of ash.| 2. Kiln for large quantity of lime, permanent structures of kilns are constructed.A. Intermittent kiln:Whenever the lime is desired intermittently or the supply of stones or fuel is not regular then the intermittent kiln is used. An intermittent kiln in which the fuel is not in contact with the lime is shown in the figure.Big pieces of limestones are used to make a sort of archon with which smaller pieces of limestone are loaded. Fire is lighted below the arch formed with big pieces of limestone. It is only the flame not the fuel that comes in contact with the stones. Burning should be gradual so that the stones forming the arch do not get split. It normally takes two days to burn and one day to cool the charge. B. Continuous kiln:Wood or charcoal could be used as a fuel. Limestones or kankars free from earth or impurities are broken into small pieces to about 5cm gauge. Alternate layers of 75 mm stone and 6mm coal dust are fed into the kiln. Top should be covered with mud, leaving a hole of 0.5 meter diameter in the center. Burning proceeds continuously and the kiln is not allowed to cool down. Burnt material is drawn out daily and fresh charge of stone and fuel is added from top. Over burnt pieces are discarded whereas the under burnt ones are reloaded into the kiln. Remaining material is slaked or ground in grinding mill for use. | a. Eminently rich lime: It slakes rapidly. It consists of less than 5% of impurities such as silica and alumina (in clay form) and high %age of CaO. It is slow in setting and hardening and setting depends on CO2 from atmosphere, therefore rich lime is used for plastering but not mortar making. It may be used for inferior and temporary structures. B. Lean and poor lime: It contains more than 5% clayey impurities and other impurities like silica, alumina, iron and magnesium oxides, exceeds 11%. Due to large amount of impurities it slakes slowly. It also sets and hardens very slowly. It is used both for plastering and mortar making for inferior class of work. Advertisements| 1. Composition:Fat lime is produced from sea shell, coral deposits etc or from lime stone containing impurities like free sand and soluble silica combined with alumina, magnesium, carbonate etc. If the proportion of free sand is large, the resulting lime becomes progressively poor and is called poor or lean lime.2. Behavior in slaking:Fat lime slakes rapidly when water is added giving out considerable heat and making hissing and cracking noise and increases 2 to 3 times its original volume. Fat lime if exposed to air, it absorbs moisture and CO2 from the atmosphere and becomes inert CaCO3 or chalk again and loses its cementing power. For developing the cementing power, quick lime must be slaked with water as early as possible, after it is obtained from the kiln.| 3. Shrinking:Fat lime has a greater tendency to shrink and crack as it dries. To prevent this, a large quantity of sand (2 to 3 times) must be mixed with it to prepare mortar.4. Hardening or setting:Fat lime is hydrated calcium oxide and sets by the absorption of CO2 from the air.Ca (OH) 2 + CO2 == CaCO3 + H2OCrystals of CaCO3 are formed and the water goes by evaporation. Thus fat lime hardens only where it comes in contact with air, as in plaster work.In the interior of thick walls, it does not acquire strength as CO2 i.e. air cannot reach there. Mixing of sand (2 to 3 times) forms pores for access of CO2 and helps hardening.5. Strength:Crystals of CaCO3 formed by fat lime are not very strong. Fat lime, therefore, does not possess much strength and is used for plastering walls, while washing etc in exposed positions.

Video game developer Essay Example for Free

Video game developer Essay Given the current pressures from competitors and substitutes, what should Nintendo do? (last Student ID digits = 0 – 3) Nowadays, electronic game industry has three dimensions: traditional video game console sector, PC and online game sector, and new emerged smartphone game sector. Historically, Nintendo was the leader in traditional video game console sector with highest profit margin than its competitive peers, Sony and Microsoft. As the technology developing, however, the whole electronic game industry is at a turning point. The difference among three sectors will become vaguer and vaguer. As Sony and Microsoft caught up the profit margin and smartphone sector emerged, Nintendo is on the cliff of revolution. Given the current pressures from competitors and substitutes, Nintendo should revolute follow: * Protect current customer base by keeping on positioning wider age range game player (i. e. from teenager to senor generation). * Overcome its graphic obstacle by building up alliance with graphic chip makers, such as NVidia. * Enhance its leadership in video game sector by keeping on investing in motion sensor game technology. In addition, touch screen might be a good complement. Next generation game will have more and more motion sensor elements, Nintendo must stand on the edge of this trend. * Construct game download platform website for game programmer and persuade them to sell their products on the website (i. e. mimic smartphone game sector to save cost for both Nintendo games suppliers and customers). * Change its customers shopping habit and provide game trails on the game download platform website. * Invade online game sector by persuading game programmer sell their game updates or complements on the Nintendo game platform website (i. e. mimic online game sector strategy to capture higher profit margin from updates). * Keep on supporting its royal and reliable game programmers/suppliers by sharing game and game platform website technology while monitoring programmers and suppliers royalty (i. e. keep on monitoring and examining Nintendo and its game suppliers alliance).

Sunday, July 21, 2019

Milnacipran Hydrochloride (MIL) Uses in Medicine

Milnacipran Hydrochloride (MIL) Uses in Medicine Milnacipran hydrochloride (MIL) is a selective serotonin and norepinephrine reuptake inhibitor. It was originally developed and manufactured by Pierre Fabre Medicament in France, and was approved in that country as an antidepressant in 1997 [1]. It has since been approved for this indication in multiple countries and currently marketed for this indication in over 45 countries worldwide including several European countries. Cypress Bioscience bought the exclusive rights for approval and marketing of the drug for fibromyalgia purpose in the United States and Canada in 2003 from the manufacturer Pierre Fabre Laboratories [2-3]. In January 2009 the U.S. Food and Drug Administration (FDA) approved MIL only for the treatment of fibromyalgia, making it the third medication approved for this purpose in the United States [4]. Some of the drug information and properties are listed below: 2.1 Physical and chemical properties Chemical name : MIL is chemically designated as (1R,2S)-rel-2(Amino-methyl)-N,N-diethyl-1-phenyl-cyclopropanecarboxamide hydrochloride and its structure is shown in Figure 2.1. Synonyms : F-2207; Ixel; Toledomin; Dalcipran; Milnacipran Hydrochloride. Empirical formula : C15H22N2O. HCl Molecular weight : 282.8 CAS No. : 101152-94-7 Melting point: 179Â °C Physical description : MIL is a white to off-white, odourless, crystalline powder. Dissociation constant (pKa) : 9.65 Permeability coefficient (Log P) : 1.42 Solubility : It is freely soluble in aqueous buffers over the entire physiological pH range. It is freely soluble in water, methanol, ethanol, chloroform, and methylene chloride and sparingly soluble in diethyl ether [5-6]. BCS class : Class I, highly soluble and highly permeable drug. 2.2 Pharmacological properties Mechanism of Action Milnacipran blocks 5-HT and norepinephrine (NE) reuptake into the neuron, thereby increasing 5-HT and NE extracellular concentrations. This activates 5-HT and NE auto and heteroreceptors culminating in a decreasing 5-HT and NE neuronal firing rates, synthesis, and release. On Chronic use MIL continues to block 5-HT and NE transporters without desensitization, but 5-HT and NE auto- and heteroreceptors are desensitized and thus, down regulated. Firing rates of 5-HT and NE return to normal, and the amount of 5-HT and NE released per nerve impulse is increased [7]. MIL has no significant affinity for ÃŽ ±- and ÃŽ ²-adrenergic, muscarinic (M1-5), histamine (H1-4), dopamine (D1-5), opiate, benzodiazepine, or ÃŽ ³-aminobutyric acid (GABA) receptors. MIL has no significant affinity for Ca2+, K+, Na+ and Cl– channels and does not inhibit the activity of human monoamine oxidases (MAO-A and MAO-B) or acetylcholinesterase [8-9]. One of the main differences between the various antidepressants and MIL is its equal preference and activity on the uptake of NE and 5-HT. The exact mechanism of the central pain inhibitory action and effectiveness in fibromyalgia symptom are unknown in Humans [10-11]. 2.3 Therapeutic Indications Treatment of depression Major Depression, also known as major depressive disorder or unipolar depression, is a highly debilitating disorder that has been estimated to affect up to 21% of the world population [12]. It is a CNS disorder characterised by a combination of symptoms that interfere with a persons ability to work, sleep, study, eat, and enjoy pleasurable activities [7,12]. Despite the advances in the treatment of depression with selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), there continue to be many unmet clinical needs with respect to both efficacy and side effects. These needs range from efficacy in treatment resistant patients, to improved onset, to reductions in side effects such as emesis or sexual dysfunction. To address these needs, there are numerous combination therapies and novel targets that have been identified that may demonstrate improvements in one or more areas [12]. Management of Fibromyalgia Fibromyalgia (FM) is a complex syndrome characterized by chronic musculoskeletal pain which is often accompanied by multiple other symptoms, including fatigue, sleep disturbances, decreased physical functioning, and dyscognition. Due to these multiple symptoms, as well as high rates of comorbidity with other related disorders, patients with FM have a reduced quality of life. The reduced serotonin and norepinephrine levels observed in patients with FM suggest that medications which increase the levels of these neurotransmitters, such as serotonin and norepinephrine reuptake inhibitors (SNRIs), may have clinically beneficial effects in FM and other chronic pain conditions. MIL is an SNRI that has been approved for the management of FM [8, 13]. MIL was viewed as a wonderful new weapon in the fight against both depression and pain. Treatment of Lupus Recent studies proved that MIL is also useful against lupus. Lupus is a chronic autoimmune disease in which the immune system turns against the body and harms healthy cells and tissues. It is a rheumatic disease which can affect many parts of the body including the joints, skin, kidneys, lungs, heart or brain. Some of the most common symptoms include extreme fatigue, painful or swollen joints, unexplained fever, skin rashes, and kidney problems. Scientific evidence indicates that lupus is caused by a combination of genetic and environmental factors. Lupus is characterized by periods of increased or intensified disease activity, called flares [14-15]. Tolerability and side effects MILhas demonstrated numerous adverse reactions in human clinical trials with tolerability decreasing with an increasing dose. In the placebo controlled trials in patients with fibromyalgia, the most frequent spontaneously reported adverse events were as follows: nausea, palpitations, headache, constipation, increased heart rate and hyperhidrosis, vomiting, and dizziness [16]. Discontinuation due to adverse reactions was generally more common among patients treated with 200 mg/day compared to 100 mg/day. The adverse effects can originate from the fluctuation in the plasma drug concentrations of an active substance following administration and subsequent metabolism and/or elimination from the body. Most of the reported adverse events were reduced or disappeared with the discontinuation of treatment [17]. 2.4 Pharmacokinetics The pharmacokinetic profile of MIL is as summarized in Table 2.1 [1,5]. Absorption MIL is well-absorbed after oral administration. Absolute bioavailability is about 85-90 %. It is not affected by food intake. The peak plasma concentration is about 120 ng/ml achieved in 2 hours after a single 50 mg dose. Inter-subject variability is low. Plasma concentrations are linearly proportional with dose over the range of single acute doses of 25 to 200 mg as shown in Table 2.2 [1,2]. Distribution Protein binding is low (13%) and not saturable. The volume of distribution of MIL is about 5 litre/kg with a total clearance of about 40 litre/hour. Renal and non-renal clearances are equivalent [1]. Metabolism MIL is metabolized mainly by conjugation (Glucoronisation). Active metabolites have been found at very low levels without clinical relevance. Cytochrome P450 2D6 is involved in the metabolism of many psychotropic drugs and its inhibition is frequently a cause of drug-drug interactions. This enzyme has no impact on the metabolism of MIL and no oxidative metabolites of MIL have been detected in humans [1-3]. The pharmacokinetics of MIL are not modified in subjects who are deficient in the CYP2D6 isoenzyme (slow sparteine-like metabolisers). Furthermore, MIL does not interfere in-vivo with other isoenzymes of cytochrome P450 [1, 18]. Elimination Plasma elimination half-life is about 8 hours. Elimination occurs mainly via the kidney with tubular secretion of the product in unchanged form. After repeated doses, MIL is totally eliminated in 2 to 3 days after termination of therapy. The liver and kidneys are both involved in the elimination of MIL as illustrated by renal and non-renal clearances with values of 23.8 Â ± 7.3 and 16.4 Â ± 3.1 l/h, respectively. This balance between renal and non-renal clearances may be an advantage in patients presenting with moderate renal insufficiency [3,5]. 2.5 Dosage and administration The recommended dose titration schedule for MIL is 12.5 mg once on Day 1, then 12.5 mg twice a day on Days 2-3, and then 25 mg twice a day on Days 4-7, and then 50 mg twice a day after Day 7. Recommended maintenance dose is 50 mg twice daily. In clinical trials, MIL was evaluated with a dose titration schedule. The daily dose may be increased to 200 mg (or 100 mg twice a day) based on individual response. Dosing should be adjusted in patients with severe renal impairment (CrCl 2.6 Marketed formulations There are various brands of MIL are available with dose of 12.5 mg, 25 mg, 50 mg and 100 mg immediate release tablets or capsules as shown in Table 2.3 [19-21].

Saturday, July 20, 2019

Nature and Logic Essay -- essays research papers

Philosophy 103: Introduction to Logic The Nature of Logic Abstract: Some of the uses of logic are illustrated, and deductive arguments are briefly distinguished from inductive arguments. I. Logic is the study of the methods and principles used in distinguishing correct from incorrect reasoning. B. Logic differs from psychology in being a normative or a prescriptive discipline rather than a descriptive discipline. 1. I.e., it prescribes how one ought to reason; it's not concerned with how one actually does reason. 2. Logic is concerned with laying down the rules for correct reasoning. 3. Consequently, logic seeks to distinguish good arguments from poor ones. II. How Logic helps reasoning: A. "Practice makes better." Some examples of how this course can help reasoning about the world are as follows. 1. Consider this syllogism: All followers of Senator Jones are in favor of higher taxes. All communists are in favor of higher taxes. All followers of Senator Jones are communists. It will become easy for us to recognize the fallacy in this argument as the fallacy of the undistributed middle term. 2. Consider this informal argument: In spite of the large number of UFO spottings that can be attributed to weather conditions and known aircraft and other factors, there are hundreds of sightings that cannot be accounted for. Hence, we can safely conclude that UFO's exit. Consider this counter-example: In spite of the large number of quarters put under kid's pillows which can be attributed to sneaky parents, brothers, sisters, and so forth, there are hundreds of cases which cannot be accounted for. Therefore, the tooth fairy exits. B. As well, this course can help with "the negative approach"—that we avoid errors by being aware of them, e.g., being aware of common formal and informal fallacies. 1. Consider the passage, "Napoleon became a great emperor because he was so short." In this short argument, the fallacy of false cause (or non causa pro causa) occurs. If this argument were good, all or most short persons would become great emperors. 2. Consider the passage, "People in developing countries get old as an earlier age, because the average life expectancy is so short in those countries." Due to infant mortality, people do not get older more quickly; the fallacy of division occurs. C. Methods, criteria, and t... ...t bottom I did not believe I had touched that man. The law of probabilities decreed me guiltless of his blood, for in all my small experience with guns I had never hit anything I had tried to hit and I knew I had done my best to hit him." 3. Or consider extrapolation techniques used in stock market prediction, e.g., the wedge formation. V. What logic is not: A. Logic is not the science of the laws of thought--in which case it would be a descriptive science like psychology. 1. Sometimes people can come to conclusions reliably without being able to know or explain how the conclusion was reached. E.g., the so-called intuitive type of personality. 2. Often people can come to the right conclusion for the wrong reasons. Logic is the study of the modes of correct reasoning as shown in an interpersonal manner. B. Logic is not really the science of reasoning either because the logician is not interested in the psychological processes of reasoning. 1. The logician is interested in the structure of arguments. 2. People infer statements and statements entail other statements. 3. We want to say that the entailment is there even though someone does not at this time understand it.

Christina Rossettie Biography :: essays research papers

Christina Rossetti was born in London on December 5, 1830 . She had two brothers and one sister, Dante Gabriel Rossetti , William Michael Rossetti and Maria Francesca Rossetti. Their father, Gabriele Rossetti, was an Italian poet and a political asylum seeker from Naples, and their mother, Frances Polidori, was the sister of Lord Byron's friend and physician, John William Polidori. Rosetti was home schooled by her mother because in the 1840's her family was stricken with severe financial difficulties due to the deterioration of her father's physical and mental health. When she was 14, Rossetti suffered a sever nervous breakdown, which in the following years was followed by sever bouts of depression and closely related illnesses. It was during this period of Rossetti's life that she, along with her mother and sister, became seriously invested in the Anglo-Catholic movement that was part of the Church of England. This religious devotion played a major role in Rossetti's personal life for the rest of her life. In her late teens she became engaged to a painter James Collinson, but there commitment eventually ended because of religious differences that they had. James Collinson reverted back to Catholicism. Some time after that Christina Rosseti became involved with the linguist by the unfamiliar name of Charles Cayley, but she did not marry him either because of, once more religious issues. For some time it was believed that Christina Rossetti was a member of the Pre-Raphaelite movement, However Christina Rossetti was never a member of the group known as the Pre-Raphaelites.She was only connected to this group because her father and her brothers were members of the group. Although she was not a member she was a crucial member of the inner circle. In fact her brothers, Dante Gabriele Rossetti and her other brother William Michael Rossetti were original founders of the Pre-Raphaelite Brother hood back in 1849, along with a few other original founders by the names of , William Holman Hunt (1827-1910), John Everett Millais (1829-1896), James Collinson, Thomas Woolner, and F. G. Stephens, in order to revitalize the arts. The Pre-Raphaelite Brotherhood (also known as the Pre-Raphaelites) was a group of English painters, poets and critics, founded in 1848. The group's intention was to reform art by rejecting what they â€Å"considered to be the mechanistic approach adopted by the Mannerist artists who followed Raphael and Michelangelo†. They believed that the Classical poses and elegant compositions of Raphael in particular had been a corrupting influence on academic teaching of art.

Friday, July 19, 2019

Postmodernism and Social Praxis Essay -- Ethics Feminism Theology Essa

Postmodernism and Social Praxis Whereas the interpreter is obliged to go to the depth of things, like an excavator, the moment of interpretation [genealogy] is like an overview, from higher and higher up, which allows the depth to be laid out in front of him in a more and more profound visibility; depth is resituated as an absolutely superficial secret.(18) So those are the changes, and I try to show those changes...(19) In Communities of Resistance and Solidarity, as well as in A Feminist Ethic of Risk, Sharon D. Welch sets forth a liberation theology in which the deconstructive processes of Michel Foucault are key. Her theology is an amalgam of Foucault's poststructuralist concepts and liberation theology's action-oriented motivation. Welch claims the genealogical methods of Foucault are ideal motivators, urging the activist to political involvement. However, Michel Foucault's genealogy was not intended for such pragmatic applications. Foucault's purpose in writing genealogies was never action-oriented. He only set out to "show those changes." By definition, genealogy never rests in one discourse or on one "truth." Foucault, as an "interpreter," emphasizes the necessary tension between keeping distance from historical discourse and awareness of one's inescapable position in historical discourse. In short, the genealogist can never rest on his or her laurels: seeming bases of "truth" are actually co nstantly changing historical constructions. While Welch claims not only to possess this type of awareness, but also to recognize its absolute necessity for her theology, she is in danger of defeating her own goals: with no solid foundations, no fixed truths, on which to base liberation theology's arguments, how can her action-... ...78. Madness and Civilization: A History of Insanity in the Age of Reason. Trans. Richard Howard. New York: Pantheon, 1965. Kaufmann, Walter, ed. The Portable Nietzsche. New York: Penguin Books, 1982. Mohanty, Chandra Talpade, Ann Russo, and Lourdes Torres. Third World Women and the Politics of Feminism. Bloomington: Indiana UP, 1991. Rabinow, Paul, ed. The Foucault Reader. New York: Pantheon, 1984. Schà ¼ssler-Fiorenza, Elizabeth. In Memory of Her: A Feminist Theological Reconstruction of Christian Origins. New York: Crossroad, 1983. Welch, Sharon D. Communities of Resistance and Solidarity: A Feminist Theology of Liberation. Maryknoll, New York: Orbis, 1985. A Feminist Ethic of Risk. Maryknoll, New York: Orbis, 1985. Winter, Gibson. Address. "Religious Social Ethics in a Postmodern World." Temple University, Philadelphia, 22 March 1995.

Thursday, July 18, 2019

Postpartum Hemorrhage Essay

Postpartum hemorrhage (PPH) is a significantly life-threatening complication that can occur after both vaginal and caesarean births (Ricci & Kyle, 2009). Simpson and Creehan (2008) define PPH as the amount of blood loss after vaginal birth, usually more than 500mL, or after a caesarean birth, normally more than 1000mL. However, the definition is arbitrary, attributed to the fact that loss of blood during birth is intuitive and widely inaccurate (Ricci & Kyle, 2009). In line with this, studies have suggested that health care providers consistently underestimate actual blood loss, thus, an objective definition of PPH would be any amount of bleeding that exposes a mother in hemodynamic jeopardy (Ricci & Kyle, 2009). Currently, PPH is the leading cause of maternal mortality worldwide, and it is estimated that, over 150, 000 women, die of the complication annually (Ricci & Kyle, 2009). Causes of Postpartum Hemorrhage Excessive bleeding can occur at any time between the separation of the placenta and its expulsion or removal, and in tandem to this, there are different facets that cause PPH (Simpson & Creehan, 2008). PPH can amount from uterine atony, failure of the uterus to contract and retract after birth (Ricci & Kyle, 2009). Uterine atony is the most common cause of PPH, accounting for 70% of cases (Sheiner, 2011), and it is usually delineated by a marked hypotonia of the uterus (Simpson & Creehan, 2008). In addition, uterine atony is likely to occur when the uterus is over distended, depicted through polyhydramnios, multiple gestations, and macrosomia (Simpson & Creehan, 2008). Other factors that induce uterine atony encompass; traumatic birth, halogenated anaesthesia, lengthened labour, induction or augmentation of labour, intraamniotic infection, tocolytics, and multiparity (Simpson & Creehan, 2008). Sheiner (2011) also affirms that trauma is a significant cause of PPH, and it is typically associated with vaginal or birth canal lacerations and uterine rupture. Vaginal delivery can amount to varying asperity of vaginal, perineum-region between the genital organs and anus-, and cervix lacerations (Sheiner, 2011). Similarly, lacerations secondary to birth trauma may occur more frequently with operative vaginal birth, through the aid of forceps or vacuum (Simpson & Creehan, 2008). The lesions can lead to a concealed retroperitoneal or suprafascial hematomas, which inevitably leads to significant but unnoticed blood loss (Sheiner, 2011). On the other hand, uterine rapture is also a form of birth trauma that can effectively amount to life-threatening PPH, as well, it is a rare obstetrical complication, with incidence of approximately 0. 6 -0. 7 % in cases of a trial of vaginal birth after caesarean section (Sheiner, 2011). Uterine rupture can become symptomatic during the postpartum period manifesting as abdominal tenderness and maternal hemodynamic collapse (Sheiner, 2011). Another cause of PPH is retained placenta, which is primarily associated with a mean duration of the third stage of labour (8-9 minutes), and Sheiner (2011) attests that longer intervals of the third stage of labour, poses as a great risk of PPH, with double the rate after ten minutes. Further, retained placental parts interpose and interfere with uterine contractions and may either cause early or late PPH (Sheiner, 2011). In conjunction to this, coagulation disorder is also a cause of PPH. It is a rare disorder that accounts only for one percent of cases (Sheiner, 2011). Other causes of PPH include; episiotomy, uterine inversion and hematomas of the vulva, which are also associated with muscle tones, tissues, stress and thrombosis (Ricci & Kyle, 2009). Clinical Presentation and Risk Factors PPH may be divided into two presentations; early PPH, which normally occurs before 24 hours, and late PPH, which usually takes place between 24 hours and six weeks (Ricci & Kyle, 2009). Moreover, symptoms of PPH vary according to the quantity and the rate of blood loss, as well as the general condition of the mother (Simpson & Creehan, 2008). The sign and symptoms of PPH include; the apparent excessive bleeding, hematocrit-reduction of the number of red blood cells, reduced blood pressure, development of symptoms of shock and anaemia, and severe pain and swelling of tissues and muscles of the vagina, vulva, pelvic and perineum (Simpson & Creehan, 2008). Besides, Ricci & Kyle (2009) avow that there are different factors that place a mother at risk for PPH, and they comprise; prolonged first, second or third stage of labour, previous history of PPH, foetal macrosomia, uterine infection, arrest of descent and multiple gestation. Other risk factors may include; mediolateral episiotomy, coagulation abnormalities, maternal hypertension, maternal exhaustion, malnutrition or anaemia, preeclampsia, precipitous birth, polyhydramnios and previous placenta previa (Ricci & Kyle, 2009). Diagnosis and Assessment The principal mode of diagnosis is a differential diagnosis, and it includes a plethora of facets; bleeding from implantation site, which may be due to uterine atony, with predisposing factors such as infections, and retained placenta or abnormal placentation (Sheiner, 2011). Coagulation disorders and trauma are also essential facets considered during diagnosis (Sheiner, 2011). Conventionally, there are different methods used for the estimation of blood loss during diagnosis, and they are majorly classified as clinical and quantitative methods (Ricci & Kyle, 2009). Clinical method remains the primary means to diagnose the magnitude of bleeding and to direct interventional therapy in obstetric practice (Ricci & Kyle, 2009). On the other hand, quantitative diagnosis entails visual assessment, which is relatively, cheap, straightforward and a standard method of observation used for measurement of blood loss (Simpson & Creehan, 2008). However, the method has a lot of inaccuracy and variation from one care-giver to another, and this is usually corrected through correlations of results obtained with clinical signs (Simpson & Creehan, 2008). In light with this, assessment is also remarkably essential, and medical history available in the prenatal record can be assessed for previous bleeding disorders in order to assist the nurse in identification of risk factors for obstetrical precursors to hemorrhage (Simpson & Creehan, 2008). Further, assessment of the woman who is bleeding begins with careful evaluation of the quantity and colour of blood loss (Simpson & Creehan, 2008). Bright red vaginal bleeding suggests active bleeding, and dark brown blood may indicate past blood loss (Simpson & Creehan, 2008). Moreover, character of the uterine activity, presence of abdominal pain, stability of maternal signs, and foetal status, also constitute the critical processes of evaluation (Simpson & Creehan, 2008). Treatment and Management Simpson and Creehan (2008) attest that the key goals of treatment and management of PPH embraces the need for stopping hemorrhage, correction of hypovolemia and homeostasis, identification of risk factors, and eventually treatment of hemorrhage and the underlying causes. Recognition of PPH requires immediate action that combines diagnostic measures with established maternal resuscitation efforts (Sheiner, 2011). Effective and successful treatment also necessitates an interdisciplinary team approach that is indispensible for life saving (Sheiner, 2011). Therapeutic management is one of the central treatment methods used in offering remedy to PPH (Ricci & Kyle, 2009). It involves and focuses on the underlying causes of the hemorrhage (Ricci & Kyle, 2009). In cases where uterine atony is the causative factor, the first step of treatment of PPH involves the evaluation of the uterus to determine if it is firmly contracted (Simpson & Creehan, 2008), thereafter, there is the incorporate uterine massage, and the use of uterotonic drugs such as oxytocin, ergot alkaloids and prostaglandins (Sheiner, 2011; Simpson & Creehan, 2008). When retained placental fragments are the cause, the fragments are separated and removed manually, and then a uterine stimulant is given to promote the uterus to expel fragments (Ricci & Kyle, 2009). Similarly, antibiotics are always administered to prevent infections and lacerations are sutured or repaired to prevent excessive bleeding (Ricci & Kyle, 2009). In addition, there is the use of desmopressin drug, a synthetic form of vasopressin (antidiuretic hormone) in reducing PPH (Ricci & Kyle, 2009). The drug stimulates the release of the stored factor VIII and von Willebrand factor from the lining of the blood vessels, which in turn increases platelet adhesiveness and shortens bleeding time (Ricci & Kyle, 2009). Other forms of medical management involve uterine packing, ligation of blood vessels-uterine, ovarian, and hypogastric arteries-, arterial embolization and bimanual compression (Simpson & Creehan, 2008). Conclusion Concisely, postpartum hemorrhage describes a mother or a woman who is experiencing or is on the verge of experiencing acute blood loss. As stated, the condition is the leading cause of maternal mortality worldwide attributed to its detrimental complication. Nevertheless, with the introduction of the various diagnoses, assessment, treatment and management methods, the condition can be corrected and loss of lives prevented. It is also advisable that individuals should be conversant with this condition, and visits to the clinics should be more frequent for pregnant women, so as to arrest and prevent such complications. ?

Wednesday, July 17, 2019

Relationships Among Service Quality

Relationships among servicing theatrical role, take in, client gratification and homage in a Hong Kong Franchised carriage Company Iris M. H. Yeung* move up Market lot of franchised spatees in Hong Kong decreases since 2004 no matter of step-up in ope arrange graphic symbol as account by thunder and Lo (2010). This paper investigates how usefulness caliber, look-alike, propitiation and commitment argon relate to gain cortical authority on the decreasing food trade character problem found on entropy peaceful from passengers of a franchised wad connection in Hong Kong in 2004.The geomorphological e graphic symbol musical shapeling results support the hypothesis that (1) receipts tonicity affects joy and run into flat, (2) role affects boilersuit blessedness and inscription runly, and (3) over all in all enjoyment affects subjection manoeuverly. However, the results do non support the hypothesis that run musical note affects committal directly. assist attribute has notwithstanding verificatory universalation on devotion through type and boilersuit joy. So even though the renovation tone whitethorn be increasing, the indirect resolution of help calibre on unwaveringty is not adapted to outgrowth grocery get by.Keywords look-alike, homage, public beam, expiation, sincere smell, geomorphologic e persona determine. Field of Study client help and client Relations Introduction In Hong Kong, public stock is the dominant convey mode, accounting for to the grittyest degree 90% of perfunctory passenger journeys over the retiring(a) 10 years ( expatriation division (1999, 2003)). Public transport comprises railways, franchised cumulationes, public light b h over-the-hills, taxi run, non-franchised tidy sum serves for residents, ferries, railway feeder potes, and rosiness tramways.Among these modes, railways and franchised lotes play an important role, carrying over sevener milli on passenger journeys per day, or approximately 70% of the conglomeration public transport patronage (Transport De objet dartment (19952010)). Market sh are of franchised lotes is largely juicyer than that of railways. In 2002, market parcel of land of franchised auto plentyes peaked at 39. 8%, whereas market share of railways at the quantify was a mere 32. 3%. However, with the fount of brand-new rails, market shares of franchised peckbares and railways were 32. 4% and 38. 8% respectively in 2010.Other than competition from another(prenominal)wise modes, franchised plentyes compete with for distributively one other as well for the operating right of new private instructor despatchs. Moreover, the franchise set up be terminated base on short(p) performance. Thus, returns prize is essential to observe market share and increase lucrativeness under fierce competition. Iris M. H. Yeung , division of care lores, City University of Hong Kong, Kowloon Tong, Kowl oon,Hong Kong, Tel. + 852-3442-8566 Fax + 852-3442-0189, email address emailprotected edu. hk (I. M. H. Yeung) YeungIn fact, tonus of parry assist of processs for some(prenominal) railways and franchised buses has continuously improved over the past years. use Mass Transit railroad track (MTR) and Kowloon Motor passenger car Limited (KMB) as references, nip and Lo (2010) commented that the calibre of rail and bus dish out provision improved from 1984 to 2004, specially in terms of overhaul of process al unhopeful-toned for and based on technical measures such(prenominal) as vehicle-kilometre per capita and real fare increase rate. However, market share of franchised buses, including KMB, started to drop since 2004 disregardless of increase in go quality as reported by tang and Lo (2010).As passengers decide on which transport mode to take, this paper investigates how proceeds quality, picture show, ecstasy and the true are related in fiat to gain insight i nto decreasing market share problem from passengers? perspective. In declination with Tang and Lo? s field of battle, the abstract is based on a data pattern collected from passengers in 2004. Further, among all the franchised bus operators in Hong Kong, KMB has the longest history and is before long the largest, occupying approximately 70% of the franchised bus share in Hong Kong. Thus, KMB? quality of suffice affects galore(postnominal) an(prenominal) people in Hong Kong it is of interest to a large share of the world and thus merits investigation. The re master(prenominal)der of the paper is organized as follows. region 2 presents the literature criticism of the four constructs and the investigate hypothesis of the proposed geomorphologic pose. Section 3 describes the inquiry modeology. The results of alpha portion analysis (EFA), confirmatory means analysis (CFA) and structural equating model (SEM) are provided in Section 4. Finally, Section 5 presents the concluding remarks with limitations of the moot and suggestions for in store(predicate) research directions.Literature Review answer quality Parasuraman et al. (1985, 1988) developed the SERVQUAL instrument, which consists of 22 attributes under v distinct dimensions (i. e. , reliability, assurance, tangibles, em cartroady, and responsiveness). They defined overhaul quality as the difference or sally amidst guests? expectations and perceived performance and proposed to use gap rack up to measure profit quality. Despite the widespread use of SERVQUAL in various industries and countries, some scholars such as Brady et al. (2002), Cronin and Taylor (1992, 1994), Zhao et al. 2002) reported that service quality is much than accurately assessed by the perceptions of quality sort of than the gap? scores. Another criticism on the SERVQUAL instrument is that the 22 associated attributes have been deemed inappropriate, or that they erectnot be s think of adopted for amount serv ice quality in all service industries (Cronin and Taylor, 1992 Lai and Chen, 2011). According to Ladhari (2009), 30 industry-specific measures of service quality have been developed between 1990 and 2007 in different industries and countries. merged calculate bodily word-painting preempt be defined as the oecumenical clinical depression that is formed in people? head words ab appear a firm (Barich and Kotler 1991). Some researchers archetype that service quality affects icon (See, for example, Ostrowski et al (1993), Aydin and Ozer (2005), Nguyen and LeBlanc 1998). Also, it has been reported that incarnate image can in like manner affect guest rapture and guest devotedty (see, for example, Hart and Rosenberger 2004). 2 Yeung Customer rejoicing According to Oliver (1997, 2010), client gaiety is defined as a judgment that a product or service provided a pleasurable take of consumption-related fulfillment. Also there are devil levels of individual consumer? ecst asy military unit-specific ecstasy and ac cumulative gladness. Transaction-specific rapture or encounter satisfaction is identified as a fulfillment reaction to a single transaction or encounter, whereas cumulative satisfaction is a judgment based on many occurrences of the selfsame(prenominal) experience and not respectable one- period experience. For twain slicknesss (encounter satisfaction and cumulative satisfaction), satisfaction is either defined as an overall judgment of satisfaction or decomposed into satisfaction with performance or quality attributes (Cronin and Taylor 1992). boilers suit cumulative satisfaction is normally utilize by researchers such as Mittal et al. 1999 and Spreng et al. 1996. subjection According to Oliver (1997 P3922010), verity is defined as a deeply held commitment to rebuy or repatronize a favored product or service consistently in the future, thereby causing repetitive same-brand or same brand-set purchasing, despite situational infl uences and marketing efforts that have the potential to cause switching behavior. on that point are two approaches to node the true behavioural and attitudinal.Behavioral loyalty refers to a client? s actual behavior to extract purchases of products or go and rootage on whereas attitudinal loyalty refers to a client? s end to repurchase and willingness to recommend. Attitudinal loyalty is more comm and use in many research studies (Loureiro and Kastenholz 2011) and relatively easy to measure. Relationships among perceived service quality, corporeal image, overall satisfaction, and loyalty at that place is much earlier research exploring the quality-satisfaction-loyalty (QSL) relationship.It is generally believed in marketing and service industries that (1) genuine service quality results in customer satisfaction, (2) good service quality attracts customers and hence lead to customer loyalty and (3) high satisfaction level is likely to construct customer loyalty. Howev er, it has withal been reported that satisfaction may not be adequate equal to lead to loyalty, though loyal customers are almost typically at ease (Cronin and Taylor 1992 Cronin et al 2000). Furthermore, bodied image is also found to affect customer satisfaction and loyalty.Customers who develop a domineering image towards a company will consort to have high customer satisfaction through a halo effect (see for example, Hart and Rosenberger 2004 Lai et al 2009). Hart and Rosenberger (2004) reported that image has a marginally portentous direct effect on customer loyalty, but a substantial effect mediated by customer satisfaction. on that pointfore, image can affect loyalty directly and indirectly. establish on the above literature look backward, this paper considers the structural model presented in Figure 1. The hypothesis proposed in the model are given below H1 value quality has a firmificant, arrogant and direct effect on orporate image. 3 Yeung H2 wait on quality h as significant, positive, and direct effect on customer satisfaction. H3 swear out quality has a significant, positive and direct effect on loyalty. H4 bodied image has a significant, positive and direct effect on customer satisfaction. H5 Corporate image has a significant, positive and direct effect on loyalty. H6 Customer satisfaction has a significant, positive and direct effect on loyalty. Methodology sample distribution and Data Collection The target population of this force field comprises purely KMB passengers.KMB has three main types of bus routes running through urban Kowloon, the novel Territories, and crossharbour. Stratified sampling was occupied to select the bus routes within each type of stratum urban Kowloon, New Territories, and cross-harbour. Passengers over 16 years old hold at the bus simoleons or stations to ride the selected bus routes and had ridden a KMB bus in the previous month were invited for interview. A total of 855 passengers were helter-skelte r selected to complete the questionnaire only 636 samples were valid and include in the analysis. Successful response rate was 74. %. To complete the questionnaire, passengers must be waiting for the bus at the bus grab. It should be noted that passengers arriving at the bus await and boarding the bus immediately with flyspeck or no waiting extremity are relatively difficult to interview. Thus, the questionnaire must be as short as possible to encourage response, taking into favor that respondents may easily lose their attention or may be in a hurry, as well as the fact that buses may arrive during the interview. The sentence for conducting the survey was scheduled from 700 a. m. to 1100 p. m. n both weekdays and weekends to interview both peak-hour and non-peak-hour passengers. The interview was conducted in Cantonese in work on 2004. Measurement and Data Analysis Based on a comprehensive review of the transport literature, detailed search on the printed materials and KMB Web sites, and results of focus groups, 15 attributes of service quality were derived. The order of these attributes in the questionnaire is as follows clarity of bus frame bearing, bus route map, bus stop location, fare, discount, bus frequency, bus promptness, bus service time, bus route coverage, travel/driving refuge, device device driver attitude (anything related to he driver other than driving such as politeness and friendliness, caring about the resort of passengers when they board get on or off the bus), bus cleanliness, back end design (such as comfort, seat layout, leg space), air-conditioning, and bus stop culture. Passengers? perception of the performance of service quality are calculated by asking them to rate each service quality attribute on a satisfaction scale (1 = precise dissatisfy and 5 = very satisfied). This type of touchstone scale is used by researchers such as Huang et al. (2006), Lin et al. (2011), and tam et al. (2005).The overall satisfactio n, in incarnated image and loyalty are heedful by a single contingent. Although the use of single-item measures may gutlessen the reckond relationships, such measures have been used successfully in many research studies (see for example, Bolton and Drew 1991 Bolton and Lemon 1999 Cronin and Taylor 1992 Brunner et al 2008 Mittal, Kumar and Tsiros 1999). As mentioned above, the questionnaire must be short enough to encourage response. Use of multi-item scales for overall satisfaction, merged image and loyalty will pixilated longer questionnaire and may affect the response rate and overall reliability.Therefore, single-item measures for these three constructs are considered adequate for this explorative engage. 4 Yeung boilers suit satisfaction is measured on a 5-point Likert scale with (1=very dissatisfied and 5 = very satisfied). As the respondents had ridden a KMB bus in the previous month, overall cumulative satisfaction is appropriate in this study. Corporate image is meas ured on a louver-point scale from very bad to very good whereas customer loyalty is measured by the intention to increase ridership in the coming month on a quintet-point scale from definitely will not to definitely will.Repurchase intention and willingness to recommend others are two common indicators of loyalty. As Hong Kong people are already old(prenominal) with KMB and its service and hence it is less requisite for the respondents to recommend KMB bus service to others, so this study uses repurchase intention only to measure loyalty. In this paper, we conduct exploratory mover analysis (EFA), confirmatory mover analysis (CFA) and structural equation model (SEM) to these data. Results and Discussion Exploratory and Confirmatory factor in Analysis Because two attributes bus route coverage? and bus stop breeding? have cross loading and low reliability problems, EFA is performed on the remaining 13 service quality attributes using commandment axis factoring extraction met hod and orthogonal rotation. The results of EFA on perceived service quality are filen in skirt 1. phoebe bird factors with eigen prize greater than one are retained. The factors are labelled as follows. performer 1 is extremely related with bus punctuality, bus frequency, and service time thus, it represents reliability. portion 2 is highly related with bus route map, bus number sign, and bus stop information thus, it represents bus travelling information. gene 3 is highly related with seat recording, air-conditioning, and cleanliness thus, it represents bus purlieu. factor out 4 is highly related with fare and discount thus, it represents determine factor. Finally, compute 5 is highly related with driver attitude and travel condom thus, it represents driving or travelling factor. Cronbach? s alpha level for the five factors varies from 0. 658 to 0. 745, which are above the generally agreed glower limit of 0. 6 and hence suggesting high internal consistency among the proteans within each factor (Nunnally and Bernstein, 1994).The results of performing CFA on the perceived service quality scores are shown in slackens 2a and 2b respectively. All goodness of function statistics shown in the bottom part of dodge 2a suggest that the quantity model for the service quality has a good tally to the data small proportion of chi- whole value to degrees of freedom (2. 03) goodness of capable indication (GFI), goodness of run into index alter for degrees of freedom (AGFI), Bentler? s comparative fit index (CFI), normed fit index (NFI), and non-normed fit index (NNFI) are greater than the doorsill value of 0. and root mean fledge residual (RMR) and root mean square error of approximation (RMSEA) are more below the sceptre value of 0. 05. The step model for the service quality also has high stiffness and reliability. Firstly, convertible factor loadings and t value of the factor loadings cosmos significantly different from zero at the 0. 001 l evel support the convergent rigorousness of all attributes. Further, as none of the correlation coefficient between the factors is greater than the square root of the AVE for the corresponding factors (see tabularise 2b), the perceived service quality scores demonstrate discriminant validity.Secondly, the complicated reliability of all five factors exceeds the minimally acceptable value of 0. 6. Moreover, four out of five factors have variance extracted predict (AVE) greater than or close to the threshold value of 0. 5. Only the bus surround? factor has an average variance estimate below the threshold value. However, this test is conservative. Therefore, as a whole, it can be reason out that the perceived service quality scores have 5 Yeung good reliability. Five summated scales are raised and used as indicators for the latent construct perceived service quality in the subsequent structural equation model.Structural equation model (SEM) A structural model is fit to the perceiv ed service quality, somatic image, overall satisfaction and loyalty data according to the model building given in Figure 1. The row between service quality and loyalty is found to be insignificant and dropped based on Wald tests. The goodness of fit indices for the revise structural model, shown in the bottom part of Table 3, suggest a good fit to the data small ratio of chisquare to degree of freedom ( 2), great values of GFI, AGFI, CFI, NFI, NNFI ( 0,9) and small RMR and RMSEA values ( 0. 05).The estimation results in Table 3 indicate that both H1 (quality ? image) and H2 (quality ? satisfaction) are strongly supported, with standardized highroad coefficients of 0. 523 and 0. 386 respectively. However, H3 (quality ? loyalty) is not supported based on insignificant standardized path coefficient. It can be seen below that service quality has only indirect effect on loyalty through overall satisfaction and corporate image. So it indicates that high service quality is not adequat e to create loyal customers for franchised bus company. The estimation results show moderate support for H4 (image ? atisfaction) with the standardized path coefficient of 0. 192 whereas weak support for H5 (image ? loyalty) and H6 (satisfaction ? loyalty), with the corresponding standardized path coefficients of 0. 105 and 0. 124 respectively. To summarize, the results support five out of six hypothesis (H1 H2, H4 H6). Furthermore, the order of the support is strong for H1 and H2, sensitive for H4 and weak for H5 and H6. In terms of instructive power, the model accounts for 26. 3% of the variance in overall satisfaction, 27. 4% of the variance in image and 3. 6% of the variance in loyalty. In other words, he model has medium informative power for both overall satisfaction and image but low explanatory power for loyalty. The low explanatory power for loyalty may imply that there is not much take on that a customer with good perceived service quality, overall satisfaction and corporate image will be loyal and repeat purchase. The management should consider other factors that affect loyalty apart from service quality, overall satisfaction and corporate image. The direct, indirect and total effects of service quality, corporate image and overall satisfaction on loyalty is given in Table 4.It is interesting to see that corporate image plays a more important role than overall satisfaction in modify loyalty, which are consistent with the findings of researchers such as Abdullah 2000. Concluding Remarks EFA concludes that there are five factors behind the perceived service quality scores. According to CFA, the measurement model for this five-factor expression performs well in terms of validity and reliability and hence five summated scales can be used as indicators for service quality in developing structural model. SEM supports the sequence service quality ? corporate image? verall satisfaction? loyalty. However, it is found that service quality affects lo yalty only indirectly through overall satisfaction and corporate image. So it may explain wherefore high service quality is not adequate to lead to customer loyalty. The table of indirect, direct and total effects of service quality, overall satisfaction and image on loyalty shows that corporate image has high total impact on loyalty, as 6 Yeung compared with satisfaction. So to increase loyalty, upward(a) the corporate image of KMB in passengers? mind is more important than improving satisfaction.As the explanatory power of these three constructs (service quality, overall satisfaction and image) for loyalty is very low (3. 6%), it seems that efforts are still needed to increase loyalty through other means. There are several limitations in this study. The generalizability of this study is limited due to three reasons. Firstly, this study used one single item only to measure overall satisfaction, corporate image and loyalty to reduce the lode of respondents and the time for the i nterview. For further research, multiple-item scales are preferred so that their validity and eliability can be assessed through CFA. Also they may evoke the interpretation and prediction of overall satisfaction and loyalty. Secondly, the analysis is based on a survey data set collected in March 2004 when the market share of franchised buses such as KMB began to decrease. 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Government of the Hong Kong special administrative region. 8 Yeung Zhao X, Bai CH, Hui YV (2002) An experiential assessment and application of SERVQUAL in a Mainland Chinese department store.Total Quality Management 13241-254. 9 Yeung Table 1 Five-factor structure of perceived service quality scores and Cronbach? s Alpha (with attributes bus route cover age? and bus stop information? being deleted) Service quality Attributes Clarity of bus number sign handler route map Bus stop location Fare can Bus frequency Bus punctuality Bus service time Bus route coverage (NA) Travel safety device driver attitude Cleanliness Seat arranging Air-conditioning Bus stop information (NA) Factor 1 Factor 2 0. 632 0. 865 0. 449 Factor 3 Factor 4 Factor 5 . 777 0. 649 0. 652 0. 902 0. 407 0. 799 0. 551 0. 520 0. 780 0. 495 Eigenvalue 4. 11 1. 44 1. 27 1. 11 Variance (%) 31. 61 11. 08 9. 76 8. 52 Cronbach? s alpha 0. 745 0. 722 0. 658 0. 726 overall MSA = 0. 797, cumulative variance explained = 68. 70%, communality = 6. 853 generator mean square residual = 0. 012, RMSP = 0. 024, Cronbach? s alpha = 0. 816 1. 01 7. 73 0. 693 10 Yeung Table 2a Results of confirmatory factor analysis on perceived service quality Loadin g 0. 728 0. 795 0. 557 0. 751 0. 765 0. 736 0. 876 0. 535 t 18. 0 1 19. 7 3 13. 4 6 16. 3 16. 4 4 19. 0 0 23. 0 8 13. 2 8 17. 5 4 14. 7 9 Reliabilit y 0. 739 0. 530 0. 632 0. 311 0. 729 0. 564 0. 585 0. 766 0. 541 0. 767 0. 286 0. 703 0. 663 0. 426 Variance Extracted 0. 491 Bus information factor Clarity of bus number sign route map Bus Bus stop location terms factor Fare Discount dependability factor Bus frequency Bus punctuality Bus service time Bus route coverage (NA) hotheaded factor Travel safety Driver attitude 0. 574 0. 532 0. 545 0. 814 0. 653 Bus environment factor 0. 663 Cleanliness 0. 677 15. 1 0. 459 9 Seat arrangement . 675 15. 1 0. 456 5 Air-conditioning 0. 531 11. 9 0. 282 2 Bus stop information (NA) conform to indices Chi-square = 130. 55, df = 55, Chi-square / df =2. 03 GFI = 0. 969, AGFI = 0. 949, CFI = 0. 966, NFI = 0. 943, NNFI = 0. 951 RMR = 0. 023, RMSEA = 0. 047 0. 399 Table 2b Correlation between factors for the measurement model on perceived service quality Bus information cost reliableness Driving Bus environment Bus information 0. 701 0. 451 0. 404 0. 474 0. 334 Price ? 0. 758 0. 45 3 0. 393 0. 340 reliableness ? ? 0. 729 0. 461 0. 438 Driving ? ? 0. 738 0. 519 Bus environment ? ? ? ? 0. 631 11 Yeung Table 3 Standardized path coefficients of the Structural Model Standardized line of reasoning estimates 0. 566 0. 558 0. 641 0. 586 0. 503 0. 523 0. 386 -t-value Hypothesis Conclusion Independent variable ? Dependent variable Service quality ? Bus information Price Reliability Driving Bus environment Corporate image Overall satisfaction Loyalty Corporate image ? Overall Satisfaction Loyalty 9. 99 -10. 71 10. 19 9. 23 9. 4 6. 6 -1 2 3 back up back up non supported 0. 192 0. 105 4. 26 2. 7 4 5 Supported Supported Overall satisfaction ? Loyalty 0. 124 2. 92 Fit indices Chi-square = 27. 7, df = 18, Chi-square / df = 1. 54 GFI = 0. 989, AGFI = 0. 978, CFI = 0. 988, NFI = 0. 967, NNFI = 0. 981 RMR = 0. 009, RMSEA = 0. 029 6 Supported 12 Yeung Table 4. take aim, Indirect and total effects on loyalty Direct Indirect -0. 105 0. 124 0. 115 0. 024 Total 0. 115 0. 129 0. 1240 Service quality Image Satisfaction Corporate image H1 Service Quality H4 H2 H6 H5 Loyalty Figure 1 Hypothetical Structural Model Satisfaction Overall H3 13